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The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2-ATPase, is a major determinant of Ca2 alternans in intact mouse hearts

Autor
Sun, B.; Wei, J.; Zhong, X.; Vallmitjana, A.; Benitez, R.
Tipus d'activitat
Article en revista
Revista
The journal of biological chemistry (Versió web)
Data de publicació
2018-07-09
Volum
293
Pàgina inicial
13650
Pàgina final
13677
DOI
https://doi.org/10.1074/jbc.RA118.003760 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/125271 Obrir en finestra nova
URL
http://www.jbc.org/content/early/2018/07/09/jbc.RA118.003760.abstract Obrir en finestra nova
Resum
Sarcoplasmic reticulum (SR) Ca2+ cycling is governed by the cardiac ryanodine receptor (RyR2) and SR Ca2+-ATPase (SERCA2a). Abnormal SR Ca2+ cycling is thought to be the primary cause of Ca2+ alternans that can elicit ventricular arrhythmias and sudden cardiac arrest. Although alterations in either RyR2 or SERCA2a function are expected to affect SR Ca2+ cycling, whether and to what extent altered RyR2 or SERCA2a function affects Ca2+ alternans is unclear. Here we employed a gain-of-function RyR2...
Citació
Sun, B., Wei, J., Zhong, X., Vallmitjana, A., Benitez, R. The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2-ATPase, is a major determinant of Ca2 alternans in intact mouse hearts. "The journal of biological chemistry (Versió web)", 9 Juliol 2018, vol. 293, p. 13650-13677.
Paraules clau
Ca2+ alternans, Ca2+ release refractoriness, Ventricular tachyarrhythmia, calcium, calcium ATPase, calcium imaging, calcium intracellular release, endoplasmic reticulum (ER), intact heart imaging, phospholamban, ryanodine receptor, sarcoplasmic reticulum (SR)
Grup de recerca
ANCORA - Anàlisi i control del ritme cardíac
B2SLab - Bioinformatics and Biomedical Signals Laboratory
CREB - Centre de Recerca en Enginyeria Biomedica

Participants

  • Sun, Bo  (autor)
  • Wei, Jinhong  (autor)
  • Zhong, Xiaowei  (autor)
  • Vallmitjana Lees, Alexander  (autor)
  • Benitez Iglesias, Raul  (autor)