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Effect of nano-structural properties of biomimetic hydroxyapatite on osteoimmunomodulation

Author
Sadowska, J.; Wei, F.; Guo, J.; Guillem-Marti, J.; Ginebra, M.P.; Xiao, Y.
Type of activity
Journal article
Journal
Biomaterials
Date of publication
2018-10
Volume
181
First page
318
Last page
332
DOI
https://doi.org/10.1016/j.biomaterials.2018.07.058 Open in new window
Repository
http://hdl.handle.net/2117/121915 Open in new window
https://www.sciencedirect.com/science/article/pii/S0142961218305490 Open in new window
Abstract
Immune cells are sensitive to the microstructural and textural properties of materials. Tuning the structural features of synthetic bone grafts could be a valuable strategy to regulate the specific response of the immune system, which in turn modulates the activity of bone cells. The aim of this study was to analyse the effect of the structural characteristics of biomimetic calcium deficient hydroxyapatite (CDHA) on the innate immune response of macrophages and the subsequent impact on osteogene...
Citation
Sadowska, J., Wei, F., Guo, J., Guillem-Marti, J., Ginebra, M.P., Xiao, Y. Effect of nano-structural properties of biomimetic hydroxyapatite on osteoimmunomodulation. "Biomaterials", Octubre 2018, vol. 181, p. 318-332.
Keywords
Calcium phosphates Biomimetic hydroxyapatite Osteoimmunomodulation Inflammation Osteogenesis Osteoclastogesis
Group of research
BBT - Biomaterials, Biomechanics and Tissue Engineering
CREB - Biomedical Engineering Research Centre
CRnE - Barcelona Research Center in Multiscale Science and Engineering

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