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How valid are the codes used to identify acute liver injury (ALI)? A study in 3 European data sources

Forns, J.; Cainzos, M.; Giner-Soriano, M.; Hellfritzsch, M.; Poblador, B.; Hallas, J.; Morros, R.; Prados-Torres, A.; Pottegard, A.; Cortes, J.; Aguado, J.; Castellsagué, J.; Jacquot, E.; Deltour, N.; Pérez-Gutthann, S.; Pladevall, M.
Type of activity
Presentation of work at congresses
Name of edition
34th International Conference on Pharmacoepidemiology & Therapeutic Risk Management
Date of publication
Presentation's date
Book of congress proceedings
34th International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE): Prague, Czech Republic: august 22-26, 2018
First page
Last page
https://onlinelibrary.wiley.com/doi/epdf/10.1002/pds.4629 Open in new window
Background: Identifying valid cases of ALI in automated data sources is challenging. Most previous case-identifying algorithms had positive predictive values (PPVs) around 50%. A case validation process was implemented in the framework of a PASS assessing the risk of ALI in users of agomelatine and other antidepressants. Objectives: To identify valid cases of ALI and evaluate the PPVs of algorithms used to detect potential ALI cases. Methods: Three data sources were used: EpiChron and SIDIAP i...
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group


  • Forns, Joan  (author and speaker )
  • Cainzos Achirica, Miguel  (author and speaker )
  • Giner Soriano, Maria  (author and speaker )
  • Hellfritzsch, M  (author and speaker )
  • Poblador Plou, Beatriz  (author and speaker )
  • Hallas, Jesper  (author and speaker )
  • Morros Padrós, Rosa  (author and speaker )
  • Prados Torres, Alexandra  (author and speaker )
  • Pottegard, Anton  (author and speaker )
  • Cortes Martinez, Jordi  (author and speaker )
  • Aguado, Jaume  (author and speaker )
  • Castellsagué, Jordi  (author and speaker )
  • Jacquot, Emmanuelle  (author and speaker )
  • Deltour, Nicole  (author and speaker )
  • Pérez Gutthann, Susana  (author and speaker )
  • Pladevall, Miquel  (author and speaker )