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Agomelatine and Risk of Hospitalisation for Acute Liver Injury: Nested Case-Control Analysis in Three European Countries

Author
Pladevall, M.; Hallas, J.; Schink, T.; Morros, R.; Poblador, B.; Forns, J.; Hellfritzsch, M.; Reinders, T.; Giner-Soriano, M.; Prados-Torres, A.; Cainzos, M.; Pottegard, A.; Kollhorst, B.; Cortes, J.; Aguado, J.; Perlemuter, G.; Castellsagué, J.; Jacquot, E.; Deltour, N.; Pérez-Gutthann, S.
Type of activity
Presentation of work at congresses
Name of edition
33rd International Conference on Pharmacoepidemiology & Therapeutic Risk Management
Date of publication
2017
Presentation's date
2017-08-29
Book of congress proceedings
33rd International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE): Montreal, Canada: august 26-30, 2017
First page
389
Last page
389
Abstract
Background: Agomelatine is a melatonergic agonist and 5-HT2C antagonist indicated for major depressive episodes in adults. Hepatotoxicity is an identified risk in the risk management plan. Objectives: To evaluate the risk of acute liver injury (ALI) associated with agomelatine and other antidepressant drugs. Methods: Multinational, multi-data source, nested case–control (incidence density sampled controls) study of new users of agomelatine (main exposure of interest), citalopram (common ref...
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Pladevall, Miquel  (author and speaker )
  • Hallas, Jesper  (author and speaker )
  • Schink, Tania  (author and speaker )
  • Morros Padrós, Rosa  (author and speaker )
  • Poblador Plou, Beatriz  (author and speaker )
  • Forns, Joan  (author and speaker )
  • Hellfritzsch, M  (author and speaker )
  • Reinders, Tammo  (author and speaker )
  • Giner Soriano, Maria  (author and speaker )
  • Prados Torres, Alexandra  (author and speaker )
  • Cainzos Achirica, Miguel  (author and speaker )
  • Pottegard, Anton  (author and speaker )
  • Kollhorst, Bianca  (author and speaker )
  • Cortes Martinez, Jordi  (author and speaker )
  • Aguado, Jaume  (author and speaker )
  • Perlemuter, Gabriel  (author and speaker )
  • Castellsagué, Jordi  (author and speaker )
  • Jacquot, Emmanuelle  (author and speaker )
  • Deltour, Nicole  (author and speaker )
  • Pérez Gutthann, Susana  (author and speaker )