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Agomelatine and other antidepressants and the risk of acute liver injury (ALI), a PASS in four European countries

Author
Pladevall, M.; Hallas, J.; Schink, T.; Morros, R.; Poblador, B.; Forns, J.; Hellfritzsch, M.; Reinders, T.; Giner-Soriano, M.; Prados-Torres, A.; Cainzos, M.; Pottegard, A.; Kollhorst, B.; Brandt, L.; Cortes, J.; Aguado, J.; Perlemuter, G.; Castellsagué, J.; Jacquot, E.; Deltour, N.; Pérez-Gutthann, S.
Type of activity
Presentation of work at congresses
Name of edition
34th International Conference on Pharmacoepidemiology & Therapeutic Risk Management
Date of publication
2018
Presentation's date
2018-08-22
Book of congress proceedings
34th International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE): Prague, Czech Republic: august 22-26, 2018
First page
19
Last page
20
URL
https://onlinelibrary.wiley.com/doi/epdf/10.1002/pds.4629 Open in new window
Abstract
Background:Agomelatine is a melatonergic agonist and 5-HT2C antagonist indicated for depression in adults. Hepatotoxicity is an identified risk in the risk management plan Objectives:To evaluate the risk of ALI associated with agomelatine and other antidepressants Methods:Nested case-control study of new users of agomelatine(main exposure), citalopram (common comparator), fluoxetine, paroxetine, sertraline, escitalopram, mirtazapine, venlafaxine, duloxetine, and amitriptyline from 2009 to 2014....
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Pladevall, Miquel  (author and speaker )
  • Hallas, Jesper  (author and speaker )
  • Schink, Tania  (author and speaker )
  • Morros Padrós, Rosa  (author and speaker )
  • Poblador Plou, Beatriz  (author and speaker )
  • Forns, Joan  (author and speaker )
  • Hellfritzsch, M  (author and speaker )
  • Reinders, Tammo  (author and speaker )
  • Giner Soriano, Maria  (author and speaker )
  • Prados Torres, Alexandra  (author and speaker )
  • Cainzos Achirica, Miguel  (author and speaker )
  • Pottegard, Anton  (author and speaker )
  • Kollhorst, Bianca  (author and speaker )
  • Brandt, Lena  (author and speaker )
  • Cortes Martinez, Jordi  (author and speaker )
  • Aguado, Jaume  (author and speaker )
  • Perlemuter, Gabriel  (author and speaker )
  • Castellsagué, Jordi  (author and speaker )
  • Jacquot, Emmanuelle  (author and speaker )
  • Deltour, Nicole  (author and speaker )
  • Pérez Gutthann, Susana  (author and speaker )