Loading...
Loading...

Go to the content (press return)

Fully coupled numerical model of actin treadmilling in the lamellipodium of the cell

Author
Kollepara, K. S.; Mulye, P. D.; Saez, P.
Type of activity
Journal article
Journal
International journal for numerical methods in biomedical engineering - Online
Date of publication
2018-12
Volume
34
Number
12
First page
1
Last page
21
DOI
https://doi.org/10.1002/cnm.3143 Open in new window
Project funding
Computational models for wound healing
Repository
http://hdl.handle.net/2117/127304 Open in new window
URL
https://onlinelibrary.wiley.com/doi/abs/10.1002/cnm.3143 Open in new window
Abstract
Cells rely on an interplay of subcellular elements for motility and migration. Certain regions of motile cells, such as the lamellipodium, are made of a complex mixture of actin monomers and filaments, which polymerize at the front of the cell, close to the cell membrane, and depolymerize at the rear. The dynamic actin turnover induces the so-called intracellular retrograde flow, and it is a fundamental process for cell motility. Apart from some comprehensive mathematical models, the computation...
Citation
Kollepara, K. S., Mulye, P. D., Saez, P. Fully coupled numerical model of actin treadmilling in the lamellipodium of the cell. "International journal for numerical methods in biomedical engineering - Online", Desembre 2018, vol. 34, núm. 12, p. 1-21.
Keywords
Actin Treadmilling, Cellular physics, Coupled-problems, Finite Element Method
Group of research
LACÀN - Numerical Methods for Applied Sciences and Engineering

Participants

  • Kollepara, Kiran Sagar  (author)
  • Mulye, Paris D.  (author)
  • Saez Viñas, Pablo  (author)