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Computational modelling suggests complex interactions between interstitial flow and tumour angiogenesis

Author
Vilanova, G.; Burés, M.; Colominas, I.; Gómez, H.
Type of activity
Journal article
Journal
Journal of the Royal Society Interface
Date of publication
2018-09-01
Volume
15
First page
1
Last page
12
DOI
https://doi.org/10.1098/rsif.2018.0415 Open in new window
Repository
http://hdl.handle.net/2117/124633 Open in new window
URL
http://rsif.royalsocietypublishing.org/content/15/146/20180415 Open in new window
Abstract
Angiogenesis, the growth of capillaries from pre-existing ones, plays a key role in cancer progression. Tumours release tumour angiogenic factors (TAFs) into the extracellular matrix (ECM) that trigger angiogenesis once they reach the vasculature. The neovasculature provides nutrients and oxygen to the tumour. In the ECM, the interstitial fluid moves driven by pressure differences and may affect the distribution of tumour TAFs, and, in turn, tumour vascularization. In this work, we propose a hyb...
Citation
Vilanova, G., Burés, M., Colominas, I., Gómez, H. Computational modelling suggests complex interactions between interstitial flow and tumour angiogenesis. "Journal of the Royal Society Interface", 1 Setembre 2018, vol. 15, p. 1-12.
Group of research
LACÀN - Numerical Methods for Applied Sciences and Engineering

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