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Viral replication modes in single-peak fitness landscapes: A dynamical systems analysis

Autor
Forners, J.; Lazaro, J. Tomás; Alarcón, T.; F. Elena, S.; Sardanyes, J.
Tipus d'activitat
Article en revista
Revista
Journal of theoretical biology
Data de publicació
2019-01-07
Volum
460
Pàgina inicial
170
Pàgina final
183
DOI
https://doi.org/10.1016/j.jtbi.2018.10.007 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/125463 Obrir en finestra nova
URL
https://www.sciencedirect.com/science/article/pii/S0022519318304776?via%3Dihub Obrir en finestra nova
Resum
Positiv e-sense, single-stranded RN A viruses are im portant pathogens infecting almost all types of organ- isms. Experimental evidence from distributions of mutations and from viral RN A ampli¿cation suggest that these pathogens may follow different RN A replication modes, r anging from the stamping machine replication (SMR) to the geo metric replication (GR) mode. Although previous theoretical work has focuse d on the evolutionary dynamics of RNA viruses amplifying their genomes with dif fer ...
Citació
Forners, J., Lazaro, J. Tomás, Alarcón, T., F. Elena, S., Sardanyes, J. Viral replication modes in single-peak fitness landscapes: A dynamical systems analysis. "Journal of theoretical biology", 7 Gener 2019, vol. 460, p. 170-183.
Paraules clau
Bifurcations, Dynamical systems, Error threshold, RNA viruses, Replication modes, Single-peak fitness landscape
Grup de recerca
SD - Sistemes Dinàmics de la UPC

Participants

  • Forners, Joan  (autor)
  • Lazaro Ochoa, Jose Tomas  (autor)
  • Alarcón, Tomás  (autor)
  • F. Elena, Santiago  (autor)
  • Sardanyes, Josep  (autor)