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Metal-enzyme nanoaggregates eradicate both gram-positive and gram-negative bacteria and their biofilms

Author
Ferreres, G.; Bassegoda, A.; Hoyo, J.; Torrent-Burgués, J.; Tzanov, T.
Type of activity
Journal article
Journal
ACS applied materials and interfaces
Date of publication
2018-11-13
Volume
10
Number
47
First page
40434
Last page
40442
DOI
https://doi.org/10.1021/acsami.8b14949 Open in new window
Repository
http://hdl.handle.net/2117/125471 Open in new window
URL
https://pubs.acs.org/doi/10.1021/acsami.8b14949 Open in new window
Abstract
To palliate the appearance of antimicrobial resistance (AMR), the use of bactericidal agents acting differently than conventional antibiotics and the elimination of bacterial biofilm, are the two most promising strategies. Here, we integrated these two complementary strategies into new antimicrobial metal-enzyme nanoaggregates (NAs) of aamylase and silver (aAgNAs) that are able to eliminate bacteria and their biofilm. The nanoparticle (NP) synthesis approach applied protein desolvation and lacca...
Citation
Ferreres, G., Bassegoda, A., Hoyo, J., Torrent, J.; Torrent-Burgués, J., Tzanov, T. Metal-enzyme nanoaggregates eradicate both gram-positive and gram-negative bacteria and their biofilms. "ACS applied materials and interfaces", 13 Novembre 2018, vol. 10, núm. 47, p. 40434-40442.
Keywords
a-amylase, antibacterial and antibiofilm effect, laccase, metal-enzyme nanoaggregates, silver
Group of research
GBMI - Molecular and Industrial Biotechnology Group

Participants