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Active superelasticity in three-dimensional epithelia of controlled shape

Author
Latorre, E.; Kale, S.; Casares, L.; Arroyo, M.
Type of activity
Journal article
Journal
Nature
Date of publication
2018-11
Volume
563
Number
7730
First page
203
Last page
208
DOI
https://doi.org/10.1038/s41586-018-0671-4 Open in new window
Project funding
Epithelial cell sheets as engineering materials: mechanics, resilience and malleability
Mechanical control of biological function
Reverse-engineering the mechanical organization and rheology of epithelial tissues
Repository
http://hdl.handle.net/2117/125924 Open in new window
https://www.researchgate.net/publication/328640507_Active_superelasticity_in_three-dimensional_epithelia_of_controlled_shape Open in new window
URL
https://www.nature.com/articles/s41586-018-0671-4 Open in new window
Abstract
Fundamental biological processes are carried out by curved epithelial sheets that enclose a pressurized lumen. How these sheets develop and withstand three-dimensional deformations has remained unclear. Here we combine measurements of epithelial tension and shape with theoretical modelling to show that epithelial sheets are active superelastic materials. We produce arrays of epithelial domes with controlled geometry. Quantification of luminal pressure and epithelial tension reveals a tensional p...
Citation
Latorre, E., Kale, S., Casares, L., Arroyo, M. Active superelasticity in three-dimensional epithelia of controlled shape. "Nature", Novembre 2018, vol. 563, núm. 7730, p. 203-208.
Group of research
LACÀN - Numerical Methods for Applied Sciences and Engineering

Participants