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RGD mutation of the heparin binding II fragment of fibronectin for guiding mesenchymal stem cell behavior on titanium surfaces

Author
Guillem-Marti, J.; Gelabert, M.; Heras, A.; Pegueroles, Marta; Ginebra, M.P.; Manero, J.
Type of activity
Journal article
Journal
ACS Applied materials and interfaces
Date of publication
2019-01-04
Volume
11
Number
4
First page
3666
Last page
3678
DOI
10.1021/acsami.8b17138
Repository
http://hdl.handle.net/2117/130220 Open in new window
URL
https://pubs.acs.org/doi/10.1021/acsami.8b17138 Open in new window
Abstract
Installing bioactivity on metallic biomaterials by mimicking the extracellular matrix (ECM) is crucial for stimulating specific cellular responses to ultimately promote tissue regeneration. Fibronectin is an ECM protein commonly used for biomaterial functionalization. The use of fibronectin recombinant fragments is an attractive alternate to the use of full-length fibronectin because of the relatively low cost and facility of purification. However, it is necessary to combine more than one fragme...
Citation
Guillem-Marti, J. [et al.]. RGD mutation of the heparin binding II fragment of fibronectin for guiding mesenchymal stem cell behavior on titanium surfaces. "ACS Applied materials and interfaces", 4 Gener 2019, vol. 11, núm. 4, p. 3666-3678.
Keywords
fibronectin, growth factor, mutation, osseointegration, recombinant protein, titanium
Group of research
BBT - Biomaterials, Biomechanics and Tissue Engineering
CREB - Biomedical Engineering Research Centre
CRnE - Barcelona Research Center in Multiscale Science and Engineering

Participants