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Amitriptyline at an environmentally relevant concentration alters the profile of metabolites beyond monoamines in gilt-head bream

Author
Ziarrusta, H.; Ribbenstedt, A.; Mijangos, L.; Picart, S.; Perera, A.; Prieto, A.; Izagirre, U.
Type of activity
Journal article
Journal
Environmental toxicology and chemistry
Date of publication
2019-01-31
First page
1
Last page
29
DOI
https://doi.org/10.1002/etc.4381 Open in new window
Repository
http://hdl.handle.net/2117/128882 Open in new window
URL
https://setac.onlinelibrary.wiley.com/doi/abs/10.1002/etc.4381 Open in new window
Abstract
The antidepressant amitriptyline is a widely used selective serotonin reuptake inhibitor that is found in the aquatic environment. The present work investigates alterations in the brain and liver metabolome of gilt-head bream (Sparus aurata) following exposure at an environmentally relevant concentration (0.2 µg/L) of amitriptyline for 7 days. Analysis of variance-simultaneous component analysis (ASCA) was used to identify metabolites that distinguished exposed from control animals. Overall, a...
Citation
Ziarrusta, H. [et al.]. Amitriptyline at an environmentally relevant concentration alters the profile of metabolites beyond monoamines in gilt-head bream. "Environmental toxicology and chemistry", 31 Gener 2019, p. 1-29.
Keywords
antidepressant, aquatic toxicology, fish, metabolomics, multivariate statistics, pharmaceuticals
Group of research
B2SLab - Bioinformatics and Biomedical Signals Laboratory
CREB - Biomedical Engineering Research Centre

Participants