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Risk of Acute Liver Injury in agomelatine and other antidepressant users in four european countries: a cohort and nested case–control study using automated health data sources

Author
Pladevall, M.; Pottegard, A.; Schink, T.; Reutfors, J.; Morros, R.; Poblador, B.; Timmer, A.; Forns, J.; Hellfritzsch, M.; Reinders, T.; Hagg, D.; Giner-Soriano, M.; Prados-Torres, A.; Cainzos, M.; Hallas, J.; Brandt, L.; Cortes, J.; Aguado, J.; Perlemuter, G.; Falissard, B.; Castellsagué, J.; Jacquot, E.; Deltour, N.; Pérez-Gutthann, S.
Type of activity
Journal article
Journal
CNS drugs
Date of publication
2019-04
Volume
33
Number
4
First page
383
Last page
395
DOI
10.1007/s40263-019-00611-9
Repository
http://hdl.handle.net/2117/171451 Open in new window
URL
https://link.springer.com/article/10.1007%2Fs40263-019-00611-9 Open in new window
Abstract
Background Agomelatine is a melatonin receptor agonist and serotonin 5-HT2C receptor antagonist indicated for depression in adults. Hepatotoxic reactions like acute liver injury (ALI) are an identified risk in the European risk management plan for agomelatine. Hepatotoxic reactions have been reported for other antidepressants, but population studies quantifying these risks are scarce. Antidepressants are widely prescribed, and users often have risk factors for ALI (e.g. metabolic syndrome). Obje...
Citation
Pladevall, M. [et al.]. Risk of Acute Liver Injury in agomelatine and other antidepressant users in four european countries: a cohort and nested case–control study using automated health data sources. "CNS drugs", Abril 2019, vol. 33, núm. 4, p. 383-395.
Keywords
ALI hospitalization, Agomelatine
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Pladevall, Miquel  (author)
  • Pottegard, Anton  (author)
  • Schink, Tania  (author)
  • Reutfors, Johan  (author)
  • Morros Padrós, Rosa  (author)
  • Poblador Plou, Beatriz  (author)
  • Timmer, Antje  (author)
  • Forns, Joan  (author)
  • Hellfritzsch, M  (author)
  • Reinders, Tammo  (author)
  • Hagg, David  (author)
  • Giner Soriano, Maria  (author)
  • Prados Torres, Alexandra  (author)
  • Cainzos Achirica, Miguel  (author)
  • Hallas, Jesper  (author)
  • Brandt, Lena  (author)
  • Cortes Martinez, Jordi  (author)
  • Aguado, Jaume  (author)
  • Perlemuter, Gabriel  (author)
  • Falissard, Bruno  (author)
  • Castellsagué, Jordi  (author)
  • Jacquot, Emmanuelle  (author)
  • Deltour, Nicole  (author)
  • Pérez Gutthann, Susana  (author)

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