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Stochastic coupled map model of subcellular calcium cycling in cardiac cells

Author
Romero, L.; Alvarez-Lacalle, E.; Shiferaw, Y.
Type of activity
Journal article
Journal
Chaos : an interdisciplinary journal of nonlinear science
Date of publication
2019-02-01
Volume
29
DOI
10.1063/1.5063462
Repository
http://hdl.handle.net/2117/132496 Open in new window
URL
https://aip.scitation.org/doi/10.1063/1.5063462 Open in new window
Abstract
In this study, we analyze a nonlinear map model of intracellular calcium (Ca) and voltage in cardiac cells. In this model, Ca release from the sarcoplasmic reticulum (SR) occurs at spatially distributed dyadic junctions that are diffusively coupled. At these junctions, release occurs with a probability that depends on key variables such as the SR load and the diastolic interval. Using this model, we explore how nonlinearity and stochasticity determine the spatial distribution of Ca release event...
Citation
Romero, L.; Alvarez-Lacalle, E.; Shiferaw, Y. Stochastic coupled map model of subcellular calcium cycling in cardiac cells. "Chaos : an interdisciplinary journal of nonlinear science", 1 Febrer 2019, vol. 29.
Group of research
BIOCOM-SC - Computational Biology and Complex Systems Group

Participants