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Synthesis and properties of diblock copolymers of omega-pentadecalactone and alpha-amino acids

Author
Tinajero, E.; Martinez de Ilarduya, A.; Muñoz, S.
Type of activity
Journal article
Journal
European polymer journal
Date of publication
2019-07-01
Volume
116
First page
169
Last page
179
DOI
10.1016/j.eurpolymj.2019.04.009
Project funding
Biobased polymers for pharmaceutical applications: Self-assemblying bio-copolyesters and modified biopolymers
Repository
http://hdl.handle.net/2117/133613 Open in new window
URL
https://www.sciencedirect.com/science/article/pii/S0014305719303283 Open in new window
Abstract
Diblock copolymers (PPDLx-b-pPAAy) were prepared from ¿-pentadecalactone and l-glutamic acid or l-lysine amino acids by ring opening polymerization initiated by amino groups. Telechelic amino-ended poly(¿-pentadecalactone) with a length of 15–20 repeating units was firstly synthesized by enzymatic polymerization by means of CALB and then used as macroinitiator for the polymerization of the N-carboxyanhydrides of the two a-amino acids conveniently protected as benzyl and eN-carbobenzoxy deriv...
Citation
Tinajero, E.; Martinez de Ilarduya, A.; Muñoz, S. Synthesis and properties of diblock copolymers of omega-pentadecalactone and alpha-amino acids. "European polymer journal", 1 Juliol 2019, vol. 116, p. 169-179.
Keywords
DDS, NCA aminoacids, Poly(pentadecalactone) amino ended, Polyester-polypeptide diblock copolymers, nanoparticles, structure, thermal properties
Group of research
POL - Advanced Industrial Polymers and Technological Biopolymers