Loading...
Loading...

Go to the content (press return)

Continuous monitoring of biofilm growth and inhibition based on QCM resonators

Type of activity
Competitive project
Funding entity
AGENCIA ESTATAL DE INVESTIGACION
Acronym
CREBIOQ
Funding entity code
RTI2018-099938-B-I00
Amount
87.120,00 €
Start date
2019-01-01
End date
2021-12-31
Keywords
QCM, antibiotic effectiveness, bacteria! biofilm growth, crecimiento biofilms bacterianos, efectividad antibióticos, electrical impedance measurement, medida impedancia eléctrica, multi-channel measurement system, sistema medida multicanal
Abstract
The search of systems for the early diagnosis and eradication of biofilms produced by microorganisms is a subject of curren! research and great interest. Microorganisms, such as bacteria, develop in their ecosystems in a communitarian way, forming colonies. In most cases, these colonies adhere themselves at interfaces of the host system in !he form of biofilms, which help them to retain nutrients and protect themselves from environmental hazards. The robustness and rapid adaptation to the environment of these communities seriously hinders their removal with biocidal agents such as antibiotics. Biofilms are particularly harmful when growing on implanted materials (for example, in prosthesis),ln this sense, the availability of electronic systems that allow the continuous monitoring of growth and, if necessary, the inhibition of these biofilms will be of great help for the progress of this research.
In the project a novel proposal is made seeking to develop a biofilm non-invasive and on-line monitoring technique by designing a multichannel measurement system based on quartz crystal resonators. This characterization system based on resonators will contribute significantly to the knowledge of the biofilm growth dynamics, accelerating the research on diagnostic, treatment and prevention techniques.

Participants