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Bayesian model selection for the study of Hardy-Weinberg proportions and homogeneity of gender allele frequencies

Author
Puig, X.; Ginebra, J.; Graffelman, J.
Type of activity
Journal article
Journal
Heredity
Date of publication
2019-05-29
DOI
10.1038/s41437-019-0232-0
Project funding
Theoretical Population Genetics
Transferring compositional data methods into applied science and technology
Repository
http://hdl.handle.net/2117/134111 Open in new window
URL
https://www.nature.com/articles/s41437-019-0232-0 Open in new window
Abstract
Standard statistical tests for Hardy-Weinberg equilibrium assume the equality of allele frequencies in the sexes, whereas tests for the equality of allele frequencies in the sexes assume Hardy–Weinberg equilibrium. This produces a circularity in the testing of genetic variants, which has recently been resolved with new frequentist likelihood and exact procedures. In this paper, we tackle the same problem by posing it as a Bayesian model comparison problem. We formulate an exhaustive set of ten...
Citation
Puig, X.; Ginebra, J.; Graffelman, J. Bayesian model selection for the study of Hardy-Weinberg proportions and homogeneity of gender allele frequencies. "Heredity", 29 Maig 2019.
Keywords
Dirichlet prior, Hardy-Weinberg equilibrium, Inbreeding coefficient, Marginal likelihood, Akaike's information criterion., Multinomial model
Group of research
ADBD - Analysis of Complex Data for Business Decisions
COSDA-UPC - COmpositional and Spatial Data Analysis

Participants