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An optimized TOPS+ comparison method for enhanced TOPS models

Author
Veeramalai, M.; Gilbert, D.; Valiente, G.
Type of activity
Journal article
Journal
BMC bioinformatics
Date of publication
2010-03-17
Volume
11
Number
138
DOI
https://doi.org/10.1186/1471-2105-11-138 Open in new window
Repository
http://hdl.handle.net/2117/12865 Open in new window
Abstract
Background: Although methods based on highly abstract descriptions of protein structures, such as VAST and TOPS, can perform very fast protein structure comparison, the results can lack a high degree of biological significance. Previously we have discussed the basic mechanisms of our novel method for structure comparison based on our TOPS+ model (Topological descriptions of Protein Structures Enhanced with Ligand Information). In this paper we show how these results can be significantly improved...
Citation
Veeramalai, M.; Gilbert, D.; Valiente, G. An optimized TOPS+ comparison method for enhanced TOPS models. "BMC bioinformatics", 17 Març 2010, vol. 11, núm. 138.
Keywords
Molecular biophysics, Molecular configurations, Optimisation, Parameter estimation, Proteins
Group of research
ALBCOM - Algorithms, Computational Biology, Complexity and Formal Methods

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