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pH-responsive diblock copolymers made of omega-pentadecalactone and ionically charged alpha-amino acids

Author
Tinajero, E.; Martinez de Ilarduya, A.; Muñoz, S.
Type of activity
Journal article
Journal
European polymer journal
Date of publication
2019-11-01
Volume
120
First page
109244:1
Last page
109244:12
DOI
10.1016/j.eurpolymj.2019.109244
Project funding
Biobased polymers for pharmaceutical applications: Self-assemblying bio-copolyesters and modified biopolymers
Repository
http://hdl.handle.net/2117/168658 Open in new window
URL
https://www.sciencedirect.com/science/article/pii/S0014305719308559 Open in new window
Abstract
Two sets of ionically charged polypentadecalactone-polypeptide diblock copolymers (PPDLx-b-PAAy, with x= 15 or 20 and y ranging from 30 to 200), one containing alpha-L-glutamic acid (LGA) and the other containing epsilon-L-lysine (LL), were obtained from their respective precursors with the side groups of LGA and LL protected as gamma-O-benzyl and epsilon-N-carbobenzoxy, respectively. The copolymers were semicrystalline with the polyester block crystallized in the usual pseudo-rhombic lattice an...
Citation
Tinajero, E.; Martinez de Ilarduya, A.; Muñoz, S. pH-responsive diblock copolymers made of omega-pentadecalactone and ionically charged alpha-amino acids. "European polymer journal", 1 Novembre 2019, vol. 120.
Keywords
Amphiphlilic block copolymers, DNA polyplexes, DOX, Drud delivery systems, Nanoparticles, Pentadecalactone, Polymacrolactone-polypeptide block copolymers
Group of research
POL - Advanced Industrial Polymers and Technological Biopolymers