Loading...
Loading...

Go to the content (press return)

Gap junction dynamics induces localized conductance bistability in cardiac tissue

Author
Hawks, C.; Elorza, J.; Witt, A.; Laroze, D.; Rodriguez Cantalapiedra, I.; Peñaranda, A.; Echebarria, B.; Bragard, J.
Type of activity
Journal article
Journal
International journal of bifurcation and chaos
Date of publication
2019-07-01
Volume
29
Number
8
First page
1930021:1
Last page
1930021:14
DOI
10.1142/S0218127419300210
Repository
http://hdl.handle.net/2117/185105 Open in new window
URL
https://www.worldscientific.com/doi/10.1142/S0218127419300210 Open in new window
Abstract
Connexins are specialized ionic channels that control the action potential propagation between cardiac myocytes. In this paper, we study the connexin dynamics in a one-dimensional model of cardiac tissue. We show that the connexin dynamics may lead to a spatial organization of the gap junction conductance. In the numerical simulations presented in this paper we have found two different regimes for the spatial organization of the conductances: (a) a spatially uniform conductance; (b) a spatially ...
Citation
Hawks, C. [et al.]. Gap junction dynamics induces localized conductance bistability in cardiac tissue. "International journal of bifurcation and chaos", 1 Juliol 2019, vol. 29, núm. 8, p. 1930021:1-1930021:14.
Keywords
Bistability, Cardiac dynamics, Chaotic dispersion, Connexins Cx43-43, Gap junction dynamics
Group of research
ANCORA - Anàlisi i control del ritme cardíac
BIOCOM-SC - Computational Biology and Complex Systems Group
GICITED - Interdisciplinary Group on Building Scienceand and Technology

Participants

Attachments