Loading...
Loading...

Go to the content (press return)

GTP binding and oncogenic K-Ras4B Protein anchored at DOPC/DOPS(4:1) Cell Membrane

Author
Huixia, L.; Marti, J.
Type of activity
Presentation of work at congresses
Name of edition
WaterEurope: Multiscale simulations and coarse-grained models for water and aqueous systems
Date of publication
2019
Presentation's date
2019-10-21
Book of congress proceedings
WaterEurope: Multiscale simulations and coarse-grained models for water and aqueous systems
First page
6
Last page
6
URL
https://www.cecam.org/wp-content/uploads/2019/10/workshop-1798IP.pdf Open in new window
Abstract
Ras plays an essential role in signal transduction pathways which ultimately turn on genes involved in cell growth, differentiation and survival so that overactive Ras signaling can lead to cancer[1]. The three major Ras isoforms are H-Ras, N-Ras, and K-Ras. K-Ras has two splice variants, K-Ras4A and K-Ras4B which is expressed at higher levels[2]. In the most cases, when Ras proteins oscillate between inactive GDP- bound and active GTP-bound states to regulate cell survival and proliferation[3]....
Group of research
SIMCON - First-principles approaches to condensed matter physics: quantum effects and complexity

Participants