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Short- and medium-term impact of bariatric surgery on the activities of CYP2D6, CYP3A4, CYP2C9, and CYP1A2 in morbid obesity

Author
Rodriguez, J.; Goday, A.; Langohr, K.; Pujadas, M.; Civit, E.; Perez, C.; Papaseit, E.; Ramon, J.; De la Torre, R.
Type of activity
Journal article
Journal
Scientific reports
Date of publication
2019-12-01
Volume
9
First page
20405:1
Last page
20405:9
DOI
10.1038/s41598-019-57002-9
Project funding
Statistical methods for clinical trials, complex censoring schemes and integrative omics data analysis
Repository
http://hdl.handle.net/2117/178993 Open in new window
URL
https://www.nature.com/articles/s41598-019-57002-9 Open in new window
Abstract
Morbid obesity and bariatric surgery induce anatomical, physiological and metabolic alterations that may alter the body’s disposition of drugs. Current literature on this topic is limited and sometimes inconsistent. Cytochrome P450 (CYP) is a superfamily of enzymes that metabolize around 75% of all marketed drugs. The purpose of this study was to evaluate the impact of body mass index and bariatric surgery on CYP activities. Firstly, we evaluated the in vivo activity of 4 major CYP isoenzymes ...
Citation
Rodriguez, J. [et al.]. Short- and medium-term impact of bariatric surgery on the activities of CYP2D6, CYP3A4, CYP2C9, and CYP1A2 in morbid obesity. "Scientific reports", 1 Desembre 2019, vol. 9, p. 20405:1-20405:9.
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Rodriguez Morato, Jose  (author)
  • Goday Arno, Albert  (author)
  • Langohr, Klaus  (author)
  • Pujadas, Mitona  (author)
  • Civit, Ester  (author)
  • Perez Maña, Clara  (author)
  • Papaseit, Esther  (author)
  • Ramon, Jose Manuel  (author)
  • De la Torre Fornell, Rafael  (author)

Attachments