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Modeling cell crawling strategies with a bistable model: from amoeboid to fan-shaped cell motion

Author
Moreno, E.; Flemming, S.; Font , F.; Holschneider, M.; Beta, C.; Alonso, S.
Type of activity
Journal article
Journal
Physica. D, Nonlinear phenomena
Date of publication
2020-11-01
Volume
412
First page
132591:1
Last page
132591:13
DOI
10.1016/j.physd.2020.132591
URL
https://www.sciencedirect.com/science/article/abs/pii/S0167278920300713 Open in new window
Abstract
Eukaryotic cell motility involves a complex network of interactions between biochemical components and mechanical processes. The cell employs this network to polarize and induce shape changes that give rise to membrane protrusions and retractions, ultimately leading to locomotion of the entire cell body. The combination of a nonlinear reaction–diffusion model of cell polarization, noisy bistable kinetics, and a dynamic phase field for the cell shape permits us to capture the key features of th...
Keywords
Amoeboid crawling, Cell motility, Dictyostelium discoideum, Keratocyte motion, Pattern formation
Group of research
BIOCOM-SC - Computational Biology and Complex Systems Group

Participants