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Structural study of a retro-enantiomer peptide with possible application in the pre-exposure prophylaxis of HIV infection

Author
Gómara, M.; Pérez, Y.; Gomez-Gutierrez, P.; Perez, J.
Type of activity
Journal article
Journal
Scientific reports
Date of publication
2020-09-02
Volume
10
Number
14430
First page
14430:1
Last page
14430:14
DOI
10.1038/s41598-020-71404-0
Repository
http://hdl.handle.net/2117/334020 Open in new window
URL
https://www.nature.com/articles/s41598-020-71404-0#article-info Open in new window
Abstract
Based on the structure of an HIV-1 entry inhibitor peptide two stapled- and a retro-enantio peptides have been designed to provide novel prevention interventions against HIV transmission. The three peptides show greater inhibitory potencies in cellular and mucosal tissue pre-clinical models than the parent sequence and the retro-enantio shows a strengthened proteolytic stability. Since HIV-1 fusion inhibitor peptides need to be embedded in the membrane to properly interact with their viral targe...
Citation
Gómara, M. [et al.]. Structural study of a retro-enantiomer peptide with possible application in the pre-exposure prophylaxis of HIV infection. "Scientific reports", 2 Setembre 2020, vol. 10, núm. 14430, p. 14430:1-14430:14.
Keywords
Antiviral peptides, HIV inhibition, Retro-inverso peptides, Structure-activity studies
Group of research
CEBIM - Molecular Biotechnology Centre
GBMI - Molecular and Industrial Biotechnology Group

Participants

  • Gómara Elena, María José  (author)
  • Pérez, Yolanda  (author)
  • Gómez Gutierrez, Patricia  (author)
  • Perez Gonzalez, Juan Jesus  (author)

Attachments