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Projection to latent spaces disentangles pathological effects on brain morphology in the asymptomatic phase of Alzheimer's disease

Author
Casamitjana, A.; Petrone, P.; Molinuevo, J.; Gispert, J. D.; Vilaplana, V.
Type of activity
Journal article
Journal
Frontiers in Neurology
Date of publication
2020-07-28
Volume
11
First page
648:1
Last page
648:11
DOI
10.3389/fneur.2020.00648
Project funding
MALEGRA, TEC2016-75976-R
Repository
http://hdl.handle.net/2117/330701 Open in new window
URL
https://www.frontiersin.org/articles/10.3389/fneur.2020.00648/full Open in new window
Abstract
Alzheimer's disease (AD) continuum is defined as a cascade of several neuropathological processes that can be measured using biomarkers, such as cerebrospinal fluid (CSF) levels of Aß, p-tau, and t-tau. In parallel, brain anatomy can be characterized through imaging techniques, such as magnetic resonance imaging (MRI). In this work we relate both sets of measurements and seek associations between biomarkers and the brain structure that can be indicative of AD progression. The goal is to uncover...
Citation
Casamitjana, A. [et al.]. Projection to latent spaces disentangles pathological effects on brain morphology in the asymptomatic phase of Alzheimer's disease. "Frontiers in Neurology", 28 Juliol 2020, vol. 11, p. 648:1-648:11.
Keywords
Alzheimer’s disease, Brain morphology, CSF biomarkers, Latent model, PLS, Pre-clinical AD
Group of research
GPI - Image and Video Processing Group
Universitat Politècnica de Catalunya

Participants

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