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Tethering of the IgG1 antibody to amorphous silica for immunosensor development: a molecular dynamics study

Author
Martí, D.; Ainsley, J.; Ahumada, Ó.; Aleman, C.; Torras, J.
Type of activity
Journal article
Journal
Langmuir
Date of publication
2020-10-27
Volume
36
Number
42
First page
12658
Last page
12667
DOI
10.1021/acs.langmuir.0c02203
Project funding
Nueva plataforma hiper-espectral para la detección simultánea y ultrasensible de marcadores infecciosos en donaciones de sangre.
Repository
http://hdl.handle.net/2117/335681 Open in new window
URL
https://pubs.acs.org/doi/10.1021/acs.langmuir.0c02203 Open in new window
Abstract
A key factor for improving the sensitivity and performance of immunosensors based on mechanical–plasmonic methods is the orientation of the antibody proteins immobilized on the inorganic surface. Although experimental techniques fail to determine surface phenomena at the molecular level, modern simulations open the possibility for improving our understanding of protein–surface interactions. In this work, replica exchange molecular dynamics (REMD) simulations have been used to model the IgG1 ...
Citation
Martí, D. [et al.]. Tethering of the IgG1 antibody to amorphous silica for immunosensor development: a molecular dynamics study. "Langmuir", 27 Octubre 2020, vol. 36, núm. 42, p. 12658-12667.
Group of research
CRnE - Barcelona Research Center in Multiscale Science and Engineering
IMEM-BRT - Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies

Participants