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Accurate early-stage colorectal cancer detection through analysis of cell-free circulating tumor DNA (ctDNA) methylation patterns.

Author
Canal, P.; Perera, A.
Type of activity
Journal article
Journal
Journal of clinical oncology
Date of publication
2021-05-20
Volume
39
Number
15_suppl
First page
3606
Last page
3606
DOI
10.1200/jco.2021.39.15_suppl.3606
URL
https://ascopubs.org/doi/abs/10.1200/JCO.2021.39.15_suppl.3606 Open in new window
Abstract
Background: Colorectal cancer (CRC) screening programs suffer from poor uptake and biomarkers have limited diagnostic accuracy. The measurement of the methylation status of tumor-derived cell-free DNA in plasma may address these challenges. We used a targeted methylation panel, tumor-derived signal deduction and machine learning algorithm to refine a blood test for the detection of early-stage CRC. Methods: This was a prospective, international multicenter observational cohort study. Plasma samp...
Group of research
B2SLab - Bioinformatics and Biomedical Signals Laboratory
CREB - Biomedical Engineering Research Centre

Participants