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CoviD-19 and brain: cognItion And meNtal heAlth

Type of activity
Competitive project
Acronym
DIANA
Funding entity
Agència de Gestió d'Ajuts Universitaris i de Recerca (Agaur)
Funding entity code
AGAUR
Start date
2021-06-01
End date
2022-12-31
Abstract
The clinical features of COVID-19 are varied, ranging from asymptomatic state to acute respiratory distress syndrome (ARDS) and multi organ dysfunction, including the central nervous system (CNS). While some cognitive and neurological effects of COVID-19 may be transient, the possibility that some become chronic cannot be ruled out. DIANA project is an interdisciplinary project that will investigate the potential discriminative power of multimodal biomarkers in COVID-19 adverse outcomes. For this challenge we will study COVID from a translational approach at the behavioral-clinical level from cognitive, emotional and functional data, the brain connectome level from structural and functional imaging data, and biogenetic level from blood and stool data. Moreover, we will develop machine learning based predictive models of cognitive, mental health, functionality and brain connectivity evolution in post COVID 19 survivors. This is an observational, descriptive, and cross-sectional study in which participants will not be randomized. Case people (adult survivors of severe COVID-19 N=134) will compare to people without that outcome (healthy adult controls n=66). It is a multicentric study where all the participants will be recruited from eleven Catalan public health institutions. The participants will be assessed on cognitive, emotional and functional status. We will obtain a blood sample to study inflammation, vascular risk, growth factors, angiogenesis, neurogenesis, and cellular metabolism biomarkers and genes, and a stool sample for gut microbiota study. Structural and functional MRI will be performed on a subgroup of participants 40 COVID-19 survivors and 40 healthy controls.
Annex al formulari
Model de la breu memòria descriptiva del projecte que cal adjuntar a la sol·licitud d’ajuts per al finançament de projectes de recerca, en el marc de la convocatòria "Replegar-se per créixer: l'impacte de les pandèmies en un món sense fronteres visibles” (PANDÈMIES 2020)
Aquest document només és vàlid per annexar-lo, en format PDF al formulari PANDÈMIES 2020, podeu emplenar el document en anglès.
This document is only valid for attaching in PDF format to be application form PANDÈMIES 2020, you can fill the document in English.

Participants