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CogNition, emotion/behAvior, fUnctionaliTy and braIn connectivity in recovered COVID-19 patientS

Type of activity
Competitive project
Funding entity
Fundació La Marató de TV3
Funding entity code
La Marato de TV3 V-00336
52.450,00 €
Start date
End date
Background and objectives: COVID-19 neurological effects can generate long-term neurobehavioral
dysfunction. Our main objective is to examine the impact of COVID-19 on neurobehavior and its relationship
with illness severity. Besides, we aim to study structural and functional brain connectivity in a subsample of
middle-aged post-COVID-19 individuals. Finally, we aim to develop predictive models of neurobehavioural
evolution in post-COVID-19 based on multimodal data.
Methods: NAUTILUS is an observational, cross-sectional, and multicenter study. It will be performed at 22
public hospitals. Two groups of COVID-19 adults (Severe N=210, Moderate-mild N=210, WHO criteria)
reporting cognitive complaints will compare to healthy controls (N=210). They will be assessed on
neurobehavioral status. We will perform brain MRI in a subsample (N=120, 40 per group), and we will obtain
potential biomarkers of neural damage (smell function, retinal blood plexuses integrity, and inflammation).
Moreover, we will use machine learning-based algorithms based on demographics, previous pathologies,
lifestyle, clinical data, and biomarkers to predict neurobehavioral models.
Expected results: Identify the neurobehavioral impact of post-COVID-19 individuals and the discriminative
power of multimodal biomarkers in adverse outcomes. Our result would help develop clinically useful models to
predict the neurobehavioral impact to develop future personalized and preventive intervention strategies.
covid-19, intel.ligència artificial