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First-in-human administration of CEB-01, a novel drug delivery implant matrix, in patients with recurrent or locally advanced retroperitoneal soft tissue sarcoma (RPS) after surgery: Preliminary safety and pharmacokinetics report

Author
González, J.; Sebio, A.; Cerdà, P.; Cano, F.; Tornero, J.; Martí, L.; Mora, J.; Giménez, L.; López, A.
Type of activity
Journal article
Journal
Journal of clinical oncology
Date of publication
2021-05-20
Volume
39
Number
15_suppl
First page
11554
Last page
11554
DOI
10.1200/JCO.2021.39.15_suppl.11554
Repository
http://hdl.handle.net/2117/350329 Open in new window
URL
https://ascopubs.org/doi/abs/10.1200/JCO.2021.39.15_suppl.11554 Open in new window
Abstract
Background: RPS local recurrence after radical surgery (SX) is frequent and a major cause of death. Locally delivered CHT by a biocompatible and biodegradable implant matrix (CEB-01) loaded with SN-38 and placed in the surgical bed during SX may increase local control and survival in RPS patients with reduced systemic toxicity. Methods: This is a multicentre, open label, first-in-human phase 1 trial comprising a dose-escalation phase (3 cohorts with total SN-38 doses of 9, 18 and 36 mg respectiv...
Citation
González, J. [et al.]. First-in-human administration of CEB-01, a novel drug delivery implant matrix, in patients with recurrent or locally advanced retroperitoneal soft tissue sarcoma (RPS) after surgery: Preliminary safety and pharmacokinetics report. "Journal of clinical oncology", 20 Maig 2021, vol. 39, núm. 15_suppl, p. 11554.
Group of research
TECTEX - Textile Technology Research Group

Participants

  • González López, José Antonio  (author)
  • Sebio García, Ana  (author)
  • Cerdà Serdà, Paula  (author)
  • Cano Casas, Francisco  (author)
  • Tornero Garcia, Jose Antonio  (author)
  • Martí, Luc  (author)
  • Mora Graupera, Jaume  (author)
  • Giménez Salinas, Lucas Krauel  (author)
  • López Pousa, Antonio  (author)