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A new gene-based association test for genome-wide association studies

Author
Buil Demur, A.; Martínez-Pérez, A.; Perera, A.; Rib, L.; Soria, J.; Caminal, P.
Type of activity
Journal article
Journal
BMC proceedings (Online)
Date of publication
2009-12-15
Volume
15
Number
3
First page
1
Last page
5
DOI
https://doi.org/10.1186/1753-6561-3-S7-S130 Open in new window
Repository
http://hdl.handle.net/2117/9715 Open in new window
URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795904/?tool=pubmed Open in new window
Abstract
Genome-wide association studies are widely used today to discover genetic factors that modify the risk of complex diseases. Usually, these methods work in a SNP-by-SNP fashion. We present a gene-based test that can be applied in the context of genome-wide association studies. We compare both strategies, SNP-based and gene-based, in a sample of cases and controls for rheumatoid arthritis. We obtained different results using each strategy. The SNP-based test found the PTPN22 gene while the gene-ba...
Citation
Buil, A. [et al.]. A new gene-based association test for genome-wide association studies. "BMC proceedings (Online)", 15 Desembre 2009, vol. 15, núm. 3, p. 1-5.
Group of research
B2SLab - Bioinformatics and Biomedical Signals Laboratory
CREB - Biomedical Engineering Research Centre

Participants

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