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The effect of atorvastatin treatment on HIV-1-infected patients interrupting antiretroviral therapy

Autor
Negredo, E.; Clotet, B.; Puig, J.; Perez, N.; Ruiz, L.; Romeu, J.; Molto, J.; Rey-Joly, C.; Blanco, J.
Tipus d'activitat
Article en revista
Revista
AIDS
Data de publicació
2006-02
Volum
20
Número
4
Pàgina inicial
619
Pàgina final
621
DOI
https://doi.org/10.1097/01.aids.0000210617.90954.0e Obrir en finestra nova
URL
https://www.ncbi.nlm.nih.gov/pubmed/16470128 Obrir en finestra nova
Resum
We conducted a pilot study to assess the effect of atorvastatin on HIV replication. Patients with stable HAART-controlled infection interrupted therapy and were randomly assigned to a control group or to start atorvastatin 40 or 80 mg/day. Statin groups showed lower serum cholesterol but similar viral loads and CD4 T-cell counts to the control group at weeks 4 and 12. Paradoxically, baseline serum cholesterol, but not atorvastatin, influenced viral rebound at week 4.
Grup de recerca
ANTENNALAB - Grup d´Antenes i Sistemes Radio

Participants

  • Negredo Puigmal, Eugènia  (autor)
  • Clotet Sala, Bonaventura  (autor)
  • Puig, Jordi  (autor)
  • Perez Alvarez, Nuria  (autor)
  • Ruiz, L  (autor)
  • Romeu Robert, Jordi  (autor)
  • Molto Marhuenda, Jose  (autor)
  • Rey-Joly Barroso, Celestino  (autor)
  • Blanco, J  (autor)