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Surface modifications of silicon nitride for cellular biosensor applications

Author
Gustavsson, J.; Altankov, G.; Errachid, A.; Samitier, J.; Planell, J. A.; Engel, E.
Type of activity
Journal article
Journal
Journal of materials science. Materials in medicine
Date of publication
2008-01
Volume
19
Number
4
First page
1839
Last page
1850
DOI
https://doi.org/10.1007/s10856-008-3384-7 Open in new window
Project funding
SMARTCAP. Biomaterial macroporoso inyectable basado en cementos de fosfato de calcio para regeneración ósea
Repository
http://hdl.handle.net/2117/8056 Open in new window
Abstract
Thin films of silicon nitride (Si3N4) can be used in several kinds of micro-sized biosensors as a material to monitor fine environmental changes related to the process of bone formation in vitro. We found however that Si3N4 does not provide optimal conditions for osseointegration as osteoblast-like MG-63 cells tend to detach from the surface when cultured over confluence. Therefore Si3N4 was modified with self-assembled monolayers bearing functional end groups of primary amine (NH2) and carboxyl...
Citation
Gustavsson, J. [et al.]. Surface modifications of silicon nitride for cellular biosensor applications. "Journal of materials science. Materials in medicine", Gener 2008, vol. 19, núm. 4, p. 1839-1850.
Group of research
CREB - Biomedical Engineering Research Centre
IMEM-BRT - Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies

Participants