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Low dose aerosol fitness at the innate phase of murine infection better predicts virulence amongst clinical strains of mycobacterium tuberculosis

Author
Cáceres, N.; Llopis, I.; Marzo, E.; Prats, C.; Vilaplana, C.; García de Viedma, D.; Samper, S.; Lopez, D.; Cardona, P.J.
Type of activity
Journal article
Journal
PloS one
Date of publication
2012-01-03
Volume
7
Number
1
First page
e29010
DOI
https://doi.org/10.1371/journal.pone.0029010 Open in new window
Repository
http://hdl.handle.net/2117/16232 Open in new window
Abstract
Background: Evaluation of a quick and easy model to determine the intrinsic ability of clinical strains to generate active TB has been set by assuming that this is linked to the fitness of Mycobacterium tuberculosis strain at the innate phase of the infection. Thus, the higher the bacillary load, the greater the possibility of inducting liquefaction, and thus active TB, once the adaptive response is set. Methodology/Principal Findings: The virulence of seven clinical Mycobacterium tuberculosis s...
Citation
Cáceres, N. [et al.]. Low dose aerosol fitness at the innate phase of murine infection better predicts virulence amongst clinical strains of mycobacterium tuberculosis. "PLoS One", 03 Gener 2012, vol. 7, núm. 1.
Group of research
SC-SIMBIO - Complex systems. Computer simulation of materials and biological systems

Participants

  • Cáceres, Neus  (author)
  • Llopis Fuste, Isaac  (author)
  • Marzo, Elena  (author)
  • Prats Soler, Clara  (author)
  • Vilaplana, Cristina  (author)
  • García de Viedma, Darío  (author)
  • Samper, Sofia  (author)
  • Lopez Codina, Daniel  (author)
  • Cardona Iglesias, Pere Joan  (author)

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